Publications
2023
Illenberger JM, Flores-Ramirez FJ, Pascasio G, Matzeu A, Martin-Fardon R. Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement. Neuropharmacology. 2023 Nov 15;239:109685. doi: 10.1016/j.neuropharm.2023.109685. Epub 2023 Aug 12. PMID: 37579870.
Illenberger JM, Flores-Ramirez FJ, Matzeu A, Lütjens R, Martin-Fardon R. ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking. Neuropharmacology. 2023 Nov 1;238:109666. doi: 10.1016/j.neuropharm.2023.109666. Epub 2023 Jul 16. PMID: 37463637.
McGregor R, Matzeu A, Thannickal T, Wu F, Cornford M, Martin-Fardon R, Siegel JM. Sensitivity of hypocretin system to chronic alcohol exposure: A human and animal study. Neuroscience. 2023 Apr 28:S0306-4522(23)00191-4. doi: 10.1016/j.neuroscience.2023.04.018. Epub ahead of print. PMID: 37121379.
Illenberger JM, Flores-Ramirez FJ, Matzeu A, Mason BJ, Martin-Fardon R. Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats. Front Pharmacol. 2023 Apr 27;14:1127735. doi: 10.3389/fphar.2023.1127735. PMID: 37180716; PMCID: PMC10172671.
2022
Flores-Ramirez FJ, Varodayan FP, Patel RR, Illenberger JM, Di Ottavio F, Roberto M, Martin-Fardon R. Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behavior in alcohol dependent rats. Br J Pharmacol. 2022 Dec 20. doi: 10.1111/bph.16015. Epub ahead of print. PMID: 36537731.
Flores-Ramirez FJ, Illenberger JM, Pascasio GE, Matzeu A, Mason BJ and Martin-Fardon R (2022) Alternative use of suvorexant (Belsomra®) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence. Front. Behav. Neurosci. 16:1085882. doi: 10.3389/fnbeh.2022.1085882
Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S, Gandhi PJ, Rodriguez L, Bajo M, D'Ambrosio S, Sun H, Kerr TM, Gonzales RA, Leggio L, Natividad LA, Haass-Koffler CL, Martin-Fardon R, Roberto M. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biol Psychiatry. 2022 Jun 15;91(12):1008-1018. doi: 10.1016/j.biopsych.2022.02.006. Epub 2022 Apr 13. PMID: 35430085; PMCID: PMC9167785.
Flores-Ramirez FJ, Matzeu A, Sánchez-Marín L, Martin-Fardon R. Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF and orexin receptor signaling. Neuropharmacology. 2022 Jun 1;210:109046. doi: 10.1016/j.neuropharm.2022.109046. Epub 2022 Mar 25. PMID: 35341789.
Laque A, Wagner GE, Matzeu A, De Ness GL, Kerr TM, Carroll AM, de Guglielmo G, Nedelescu H, Buczynski MW, Gregus AM, Jhou TC, Zorrilla EP, Martin-Fardon R, Koya E, Ritter RC, Weiss F, Suto N. Linking drug and food addiction via compulsive appetite. Br J Pharmacol. 2022 Jun;179(11):2589-2609. doi: 10.1111/bph.15797. Epub 2022 Mar 7. PMID: 35023154; PMCID: PMC9081129.
Matzeu A, Martin-Fardon R. Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value. Front Behav Neurosci. 2022 Jan 20;15:787595. doi: 10.3389/fnbeh.2021.787595. PMID: 35126069; PMCID: PMC8811192.
2021
Matzeu A, Martin-Fardon R. Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats. J Psychiatry Neurosci. 2021 Jul 28;46(4):E459-E471. doi: 10.1503/jpn.200213. PMID: 34318655; PMCID: PMC8519495.
Pavón FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH, Serrano A. Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex. Neurobiol Stress. 2021 Jan 9;14:100293. doi: 10.1016/j.ynstr.2021.100293. PMID: 33490317; PMCID: PMC7809503.
Matzeu A, Martin-Fardon R. Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. Front Behav Neurosci. 2021 Feb 23;15:620868. doi: 10.3389/fnbeh.2021.620868. PMID: 33708078; PMCID: PMC7940839.
2020
Matzeu A, Martin-Fardon R. Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence. Front Integr Neurosci. 2020 Nov 10;14:599710. doi: 10.3389/fnint.2020.599710. PMID: 33240054; PMCID: PMC7683390.
Pavon FJ, Polis I, Stouffer DG, Roberto M, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH, Serrano A. COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats. Alcohol Clin Exp Res. 2020 Nov;44(11):2158-2165. doi: 10.1111/acer.14456. Epub 2020 Oct 3. PMID: 32944989; PMCID: PMC7680444.
Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodríguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addict Biol. 2020 Sep;25(5):e12813. doi: 10.1111/adb.12813. Epub 2019 Jul 24. PMID: 31339221; PMCID: PMC8050940.
Matzeu A, Martin-Fardon R. Targeting the Orexin System for Prescription Opioid Use Disorder. Brain Sci. 2020 Apr 10;10(4):226. doi: 10.3390/brainsci10040226. PMID: 32290110; PMCID: PMC7225970.
Matzeu A, Martin-Fardon R. Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats. Neuropharmacology. 2020 Mar 1;164:107906. doi: 10.1016/j.neuropharm.2019.107906. Epub 2019 Dec 4. PMID: 31841797; PMCID: PMC6954966.
Kim JS, Martin-Fardon R. Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol- Seeking Behavior. Alcohol Clin Exp Res. 2020 Feb;44(2):354-367. doi: 10.1111/acer.14264. Epub 2020 Jan 2. PMID: 31840823; PMCID: PMC7018591.