Publications
2025
Illenberger, Jessica & Flores Ramirez, Francisco & Matzeu, Alessandra & Lutjens, Robert & Martin-Fardon, Rémi. (2025). ADX106772, an mGlu2 Receptor Positive Allosteric Modulator, Selectively Attenuates Oxycodone- but not Sweetened Condensed Milk-Seeking Behavior. Drug and Alcohol Dependence. 267. 112005. 10.1016/j.drugalcdep.2024.112005.
2024
Oasa, S., Sezgin, E., Ma, Y., Horne, D. A., Radmilović, M. D., Jovanović-Talisman, T., Martin-Fardon, R., Vukojević, V., & Terenius, L. (2024). Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane. Translational psychiatry, 14(1), 477. https://doi.org/10.1038/s41398-024-03172-8
Flores-Ramirez, F. J., Illenberger, J. M., & Martin-Fardon, R. (2024). Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior. Neurobiology of stress, 33, 100695. https://doi.org/10.1016/j.ynstr.2024.100695
Illenberger JM, Flores-Ramirez FJ, Pascasio G, Franco M, Mendonsa B, Martin-Fardon R. Pivotal role of orexin signaling in the posterior paraventricular nucleus of the thalamus during the stress-induced reinstatement of oxycodone-seeking behavior. Journal of Psychopharmacology (Oxford, England). 2698811241260989. PMID 38888086 DOI: 10.1177/02698811241260989
Flores-Ramirez FJ, Illenberger JM, Pascasio G, Terenius L, Martin-Fardon R. LY2444296, a κ-opioid receptor antagonist, selectively reduces alcohol drinking in male and female Wistar rats with a history of alcohol dependence. Scientific Reports. 14: 5804. PMID 38461355 DOI: 10.1038/s41598-024-56500-9
2023
Illenberger JM, Flores-Ramirez FJ, Pascasio G, Matzeu A, Martin-Fardon R. Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement. Neuropharmacology. 2023 Nov 15;239:109685. doi: 10.1016/j.neuropharm.2023.109685. Epub 2023 Aug 12. PMID: 37579870.
Illenberger JM, Flores-Ramirez FJ, Matzeu A, Lütjens R, Martin-Fardon R. ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking. Neuropharmacology. 2023 Nov 1;238:109666. doi: 10.1016/j.neuropharm.2023.109666. Epub 2023 Jul 16. PMID: 37463637.
McGregor R, Matzeu A, Thannickal T, Wu F, Cornford M, Martin-Fardon R, Siegel JM. Sensitivity of hypocretin system to chronic alcohol exposure: A human and animal study. Neuroscience. 2023 Apr 28:S0306-4522(23)00191-4. doi: 10.1016/j.neuroscience.2023.04.018. Epub ahead of print. PMID: 37121379.
Illenberger JM, Flores-Ramirez FJ, Matzeu A, Mason BJ, Martin-Fardon R. Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats. Front Pharmacol. 2023 Apr 27;14:1127735. doi: 10.3389/fphar.2023.1127735. PMID: 37180716; PMCID: PMC10172671.
2022
Flores-Ramirez FJ, Varodayan FP, Patel RR, Illenberger JM, Di Ottavio F, Roberto M, Martin-Fardon R. Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behavior in alcohol dependent rats. Br J Pharmacol. 2022 Dec 20. doi: 10.1111/bph.16015. Epub ahead of print. PMID: 36537731.
Flores-Ramirez FJ, Illenberger JM, Pascasio GE, Matzeu A, Mason BJ and Martin-Fardon R (2022) Alternative use of suvorexant (Belsomra®) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence. Front. Behav. Neurosci. 16:1085882. doi: 10.3389/fnbeh.2022.1085882
Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S, Gandhi PJ, Rodriguez L, Bajo M, D'Ambrosio S, Sun H, Kerr TM, Gonzales RA, Leggio L, Natividad LA, Haass-Koffler CL, Martin-Fardon R, Roberto M. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biol Psychiatry. 2022 Jun 15;91(12):1008-1018. doi: 10.1016/j.biopsych.2022.02.006. Epub 2022 Apr 13. PMID: 35430085; PMCID: PMC9167785.
Flores-Ramirez FJ, Matzeu A, Sánchez-Marín L, Martin-Fardon R. Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF and orexin receptor signaling. Neuropharmacology. 2022 Jun 1;210:109046. doi: 10.1016/j.neuropharm.2022.109046. Epub 2022 Mar 25. PMID: 35341789.
Laque A, Wagner GE, Matzeu A, De Ness GL, Kerr TM, Carroll AM, de Guglielmo G, Nedelescu H, Buczynski MW, Gregus AM, Jhou TC, Zorrilla EP, Martin-Fardon R, Koya E, Ritter RC, Weiss F, Suto N. Linking drug and food addiction via compulsive appetite. Br J Pharmacol. 2022 Jun;179(11):2589-2609. doi: 10.1111/bph.15797. Epub 2022 Mar 7. PMID: 35023154; PMCID: PMC9081129.
Matzeu A, Martin-Fardon R. Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value. Front Behav Neurosci. 2022 Jan 20;15:787595. doi: 10.3389/fnbeh.2021.787595. PMID: 35126069; PMCID: PMC8811192.
2021
Matzeu A, Martin-Fardon R. Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats. J Psychiatry Neurosci. 2021 Jul 28;46(4):E459-E471. doi: 10.1503/jpn.200213. PMID: 34318655; PMCID: PMC8519495.
Pavón FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH, Serrano A. Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex. Neurobiol Stress. 2021 Jan 9;14:100293. doi: 10.1016/j.ynstr.2021.100293. PMID: 33490317; PMCID: PMC7809503.
Matzeu A, Martin-Fardon R. Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. Front Behav Neurosci. 2021 Feb 23;15:620868. doi: 10.3389/fnbeh.2021.620868. PMID: 33708078; PMCID: PMC7940839.